Table 3. llele frequency distribution by sex and age group for three SNPs in TSPAN18.

			Case		Control
Group	SNP	A1/A2†	n	Freq. §	n	Freq. §	P*
Male
	rs11038167	A/C	554/838	0.40	429/713	0.38	0.2725
	rs11038172	A/G	613/769	0.44	467/673	0.41	0.09324
	rs835784	A/G	420/968	0.30	293/849	0.26	0.01374
Female
	rs11038167	A/C	323/469	0.41	377/521	0.42	0.6192
	rs11038172	A/G	352/438	0.45	395/485	0.45	0.893
	rs835784	A/G	247/545	0.31	250/648	0.28	0.1251
Younger (−29)
	rs11038167	A/C	53/99	0.35	91/99	0.48	0.02013
	rs11038172	A/G	58/94	0.38	97/93	0.51	0.02125
	rs835784	A/G	39/113	0.26	61/129	0.32	0.2074
Middle-aged (30–59)
	rs11038167	A/C	678/1044	0.39	657/1041	0.39	0.6924
	rs11038172	A/G	756/960	0.44	703/977	0.42	0.1983
	rs835784	A/G	523/1201	0.30	438/1262	0.26	0.00339
Elderly (60-)
	rs11038167	A/C	146/164	0.47	58/94	0.38	0.07142
	rs11038172	A/G	151/153	0.50	62/88	0.41	0.09996
	rs835784	A/G	105/199	0.35	44/106	0.29	0.2691

^†A1/A2, indicates minor allele/major allele.

^§The minor allele frequency.

^*Cochran-Armitage trend test p-values for minor allele.