Table 2. Genes differentially expressed in liver tissue of 14 days old TK2+/+ and TK2−/− mice identified by a PCR-focused array.
| Gene name | Fold change (TK2−/−/TK2+/+) |
| Acetyl-Coenzyme A acyltransferase 1A | −4.3 |
| Acetyl-Coenzyme A acyltransferase 2(mitochondrial 3-oxoacyl-Coenzyme A thiolase) | −4.0 |
| Acyl-Coenzyme A dehydrogenase family, member 10 | −2.6 |
| Acyl-Coenzyme A dehydrogenase family, member 9 | −4.1 |
| Acyl-Coenzyme A dehydrogenase, long-chain | −2.2 |
| Acetyl-Coenzyme A acetyltransferase 1 | −4.8 |
| Acetyl-Coenzyme A acetyltransferase 2 | −4.4 |
| Acyl-CoA thioesterase 3 | −7.5 |
| Acyl-CoA synthetase long-chain family member 1 | −4.0 |
| Acyl-CoA synthetase long-chain family member 3 | −4.5 |
| Acyl-CoA synthetase long-chain family member 4 | 2.2 |
| Acyl-CoA synthetase medium-chain family member 5 | −6.8 |
| 3-hydroxybutyrate dehydrogenase, type 1 | −34.8 |
| 3-hydroxybutyrate dehydrogenase, type 2 | −7.4 |
| Carnitine palmitoyltransferase 1a, liver | −2.9 |
| Carnitine palmitoyltransferase 1b, muscle | 2.2 |
| Carnitine palmitoyltransferase 2 | −3.1 |
| Carnitine O-octanoyltransferase | −13.4 |
| 2.4-dienoyl CoA reductase 1, mitochondrial | −5.1 |
| Fatty acid binding protein 1, liver | −2.7 |
| Fatty acid binding protein 2, intestinal | −44.3 |
| Fatty acid binding protein 3, muscle and heart | −3.5 |
| Fatty acid binding protein 5, epidermal | −2.5 |
| Fatty acid binding protein 6, ileal (gastrotropin) | −3.9 |
| Glycerol kinase 2 | −2.7 |
| Glycerol phosphate dehydrogenase 2, mitochondrial | −4.4 |
| Glycerol kinase | −3.3 |
| Hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-CoenzymeA thiolase/enoyl-Coenzyme A hydratase(trifunctional protein), alpha subunit | −4.2 |
| 3-hydroxy-3-methylglutaryl-Coenzyme A lyase | −2.8 |
| 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 | −3.2 |
| 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 | −3.7 |
| Lipase, hormone sensitive | −2.4 |
| 3-oxoacid CoA transferase 2A | −3.4 |
| Peroxisomal trans-2-enoyl-CoA reductase | −5.4 |
| Pyrophosphatase (inorganic) 1 | −2.4 |
| Protein kinase, AMP-activated, alpha 1 catalytic subunit | −2.7 |
| Protein kinase, AMP-activated, beta 1 non-catalytic subunit | −2.2 |
| Protein kinase, AMP-activated, beta 2 non-catalytic subunit | −2.7 |
| Protein kinase, cAMP dependent, catalytic, alpha | −2.4 |
| Protein kinase, cAMP dependent, catalytic, beta | −2.4 |
| Protein kinase, AMP-activated, gamma 2 non-catalytic subunit | −2.2 |
| Protein kinase, AMP-activated, gamma 3 non-catatlytic subunit | 2.3 |
| Solute carrier family 27 (fatty acid transporter), member 3 | −4.6 |
Data are expressed as mean fold change in TK2−/− samples relative to TK2+/+ control samples. The data analysis, including statistical comparisons, were done using Qiagen’s software RT2 Profiler PCR Array Data Analysis version 3.5. Genes of TK2−/− mice (n = 3) that differed by >2-fold compared with TK2+/+ controls (n = 3) are included and highlighted in bold when p≤0.05.