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. 2013 Mar 7;8(3):e58696. doi: 10.1371/journal.pone.0058696

Figure 6. Effect of DNA encoding MB12/22 on the development of articular damages in the model of antigen-induced arthritis in rats.

Figure 6

Rats were treated with mBSA 3 days after intraarticular injection of PBS, DMRI-C + MB12/22 DNA or DMRI-C + control DNA. Saline-treated groups represent a negative control group in order to show a normal synovia. Three days later, animals were euthanized and synovia tissues were analyzed. Note the synovial hyperplasia and leukocyte infiltration in the mBSA alone, mBSA + DMRI-C treated rats, as compared with the clearly milder synovial alterations of synovium in the DMRI-C + MB12/22 DNA rat. Original magnification 250×. A tissue damage score was determined as the degree of synovial hyperplasia, cell infiltration, vascular lesions, and tissue fibrosis. Values are the mean ± SD of 5 rats per group. (*): P values less than or equal to 0.02 were considered significant.