Figure 2. Overlap of the set of differentially regulated genes in HK-2 cells in response to urines from Decliners and Non-decliners and the corresponding sets of genes in tubular and interstitial compartments of kidney biopsies obtained from patients with advanced DN.

Panel A: Down-regulated genes in HK-2 cells and in tubular and interstitial compartments of kidney biopsies (P-value  = 0.34 for overlap with data of Woroniecka et al. [12] and 0.43 for overlap with data of Schmid et al. [11]). Panel B: Up-regulated genes in HK-2 cells and in tubular and interstitial compartments of kidney biopsies (P-value <10⁻⁹ for overlap with data of Woroniecka et al. [12] and <10⁻⁴ for overlap with data of Schmid et al. [11]).