Table 6. Enriched GO biological process terms for 194 down-regulated genes in HK2 cells (top 20 significantly enriched BP terms (P<0.01) were retrieved upstream towards its ancestors to level 4).

GO Term IDs	GO Term	# Genes observed	# Genes expected	# Genes total	List of observed genes
19222	Regulation of metabolic process	47	33.46	3691	AHR, AIRE, ATG10, BLZF1, CDC14B, CDC25B, CREB1, DLC1, DUSP1, DUSP19, DUSP5, FOXL2, GABPB2, HIPK2, ID1, ID2, ITCH, ITGB3, KCNH6, LRRFIP1, MAP3K9, MITF, MSH3, NFAT5, NFATC3, NPR1, OVOL2, PCSK9, PTGS2, PXN, SMAP1, SYDE2, TADA3, USP14, ZNF14, ZNF33A, ZNF417, ZNF430, ZNF454, ZNF542, ZNF549, ZNF620, ZNF667, ZNF786, ZNF791, ZNF91, ZNF98
6139	Nucleobase-containing compound metabolic process	47	38.00	4192	AHR, AIRE, BLZF1, C9orf80, CDC14B, CREB1, DBF4, DMC1, EXOSC2, FOXL2, GABPB2, GTF3C6, HIPK2, ID1, ID2, INTS3, ITCH, KCNH6, LRRFIP1, MCM8, MITF, MSH3, NAT14, NFAT5, NFATC3, OVOL2, RAD51L1, RPL21, RPSA, SMG1, SRRM2, TADA3, TEP1, TTF2, ZNF14, ZNF33A, ZNF417, ZNF430, ZNF454, ZNF542, ZNF549, ZNF620, ZNF667, ZNF786, ZNF791, ZNF91, ZNF98
90304	Nucleic acid metabolic process	35	31.27	3449	AHR, AIRE, BLZF1, CREB1, FOXL2, GABPB2, GTF3C6, HIPK2, ID1, ID2, ITCH, KCNH6, LRRFIP1, MITF, NAT14, NFAT5, NFATC3, OVOL2, RPL21, RPSA, TADA3, TTF2, ZNF14, ZNF33A, ZNF417, ZNF430, ZNF454, ZNF542, ZNF549, ZNF620, ZNF667, ZNF786, ZNF791, ZNF91, ZNF98
44260	Cellular macromolecule metabolic process	67	50.93	5618	AHR, AIRE, ATG10, BLZF1, C9orf80, CDC14B, CDC25B, CREB1, DBF4, DLC1, DMC1, DUSP1, DUSP19, DUSP5, EXOSC2, FOXL2, FUT6, GABPB2, GNPNAT1, GTF3C6, HIPK2, ID1, ID2, INTS3, ITCH, ITGB3, KCNH6, LRRFIP1, MAP3K9, MCM8, MITF, MRP63, MSH3, MSRB3, NAT14, NFAT5, NFATC3, NPR1, OVOL2, PCSK9, PPME1, PXN, RAD51L1, RPL21, RPSA, SMG1, SRRM2, SUV39H2, TADA3, TEP1, TTF2, TTLL12, USP14, WDR82, ZNF14, ZNF33A, ZNF417, ZNF430, ZNF454, ZNF542, ZNF549, ZNF620, ZNF667, ZNF786, ZNF791, ZNF91, ZNF98
33554	Cellular response to stress	16	7.77	857	ATG10, C9orf80, CDC14B, CREB1, DUSP19, HIPK2, INTS3, ITCH, MAP3K9, MSH3, PCSK9, PXN, RAD51L1, SMG1, XIAP, ZMAT3
9059	Macromolecule biosynthetic process	42	29.01	3200	AHR, AIRE, ATG10, BLZF1, CREB1, DBF4, FOXL2, FUT6, GABPB2, GNPNAT1, GTF3C6, HIPK2, ID1, ID2, ITCH, ITGB3, KCNH6, LRRFIP1, MCM8, MITF, MRP63, NAT14, NFAT5, NFATC3, OVOL2, RPL21, RPSA, TADA3, TTF2, ZNF14, ZNF33A, ZNF417, ZNF430, ZNF454, ZNF542, ZNF549, ZNF620, ZNF667, ZNF786, ZNF791, ZNF91, ZNF98