Table 7. List of 41 up-regulated genes overlapping between: A) up-regulated genes in HK-2 cells exposed to urines from Decliners and B) up-regulated genes in tubular and interstitial compartment of kidney biopsies obtained from patients with advanced diabetic nephropathy (genes strongly negatively correlated with eGFR).
| A) Findings in HK-2 cells: | B) Findings in tubular/interstitial compartment: | ||||||||
| Gene Name | Entrez ID | Fold change | (p) | Fold change | (p) | Woroniecka's datasetSpearman Correlation | Schmid's datasetSpearman Correlation | ||
| 6 hrs expos. | 24 hrs expos. | (r) | (p) | (r) | (p) | ||||
| Genes up-regulated during both exposures | |||||||||
| ADRB2 | 154 | 2.13 | 0.009 | 1.36 | 0.002 | −0.77 | 0.00 | ||
| BIRC3 | 330 | 1.40 | 0.126 | 1.77 | 0.019 | −0.67 | 0.00 | −0.68 | 0.01 |
| CCL2 | 6347 | 2.27 | 0.011 | 1.98 | 8xE-04 | −0.70 | 0.00 | ||
| CCL5 | 6352 | 2.24 | 0.001 | 1.83 | 4xE-05 | −0.76 | 0.00 | ||
| IL8 | 3576 | 7.23 | 0.006 | 3.23 | 0.004 | −0.59 | 0.00 | ||
| JAK1 | 3716 | 1.75 | 0.035 | 1.73 | 0.017 | −0.49 | 0.01 | ||
| LOX | 4015 | 1.43 | 0.050 | 1.67 | 0.041 | −0.60 | 0.03 | ||
| LCN2 | 3934 | 1.87 | 0.002 | 5.20 | 1xE-04 | −0.59 | 0.00 | ||
| NAMPT | 10135 | 1.51 | 0.004 | 1.33 | 0.085 | −0.49 | 0.06 | ||
| NBN | 4683 | 1.34 | 0.017 | 1.39 | 0.027 | −0.44 | 0.02 | −0.46 | 0.08 |
| PTX3 | 5806 | 1.86 | 0.009 | 1.31 | 0.002 | −0.51 | 0.06 | ||
| SLPI | 6590 | 1.76 | 0.004 | 2.76 | 9xE-04 | −0.69 | 0.00 | −0.46 | 0.08 |
| SOD2 | 6648 | 1.69 | 0.003 | 1.84 | 0.001 | −0.74 | 0.00 | ||
| ST5 | 6764 | 1.92 | 0.022 | 1.31 | 0.005 | −0.75 | 0.00 | ||
| TFRC | 7037 | 1.47 | 0.034 | 1.73 | 0.002 | −0.49 | 0.06 | ||
| TNFAIP2 | 7127 | 2.51 | 0.004 | 1.45 | 0.005 | −0.80 | 0.00 | ||
| TNFRSF1B | 7133 | 1.84 | 0.009 | 1.36 | 0.013 | −0.68 | 0.00 | ||
| Genes up-regulated during 6 hrs. exposure: | |||||||||
| BCL2A1 | 597 | 2.59 | 0.005 | 1.17 | 0.024 | −0.62 | 0.00 | ||
| DDR1 | 780 | 1.31 | 0.015 | 1.13 | 0.173 | −0.58 | 0.00 | −0.51 | 0.05 |
| DSE | 29940 | 1.82 | 0.031 | 1.25 | 0.155 | −0.59 | 0.00 | −0.55 | 0.04 |
| FOSL2 | 2355 | 1.50 | 0.010 | 1.25 | 0.004 | −0.51 | 0.05 | ||
| ICAM1 | 3383 | 1.51 | 0.003 | 1.20 | 0.103 | −0.61 | 0.00 | −0.47 | 0.07 |
| KIF2A | 3796 | 1.34 | 0.026 | 1.09 | 0.015 | −0.53 | 0.01 | −0.65 | 0.01 |
| LAMB3 | 3914 | 1.84 | 0.046 | 1.28 | 0.006 | −0.55 | 0.00 | ||
| LYN | 4067 | 1.47 | 0.031 | 1.14 | 0.131 | −0.80 | 0.00 | ||
| MYO1B | 4430 | 1.39 | 0.042 | 1.25 | 0.010 | −0.50 | 0.01 | −0.55 | 0.04 |
| NAP1L1 | 4673 | 1.46 | 0.030 | 1.13 | 0.601 | −0.69 | 0.00 | −0.46 | 0.07 |
| NFKB1 | 4790 | 1.77 | 0.013 | 1.17 | 0.024 | −0.71 | 0.01 | ||
| RAC2 | 5880 | 1.34 | 0.008 | 1.20 | 0.017 | −0.75 | 0.00 | ||
| SERPINB8 | 5271 | 1.58 | 0.036 | 0.99 | 0.826 | −0.50 | 0.06 | ||
| SLC43A3 | 29015 | 1.36 | 0.007 | 1.11 | 0.131 | −0.56 | 0.00 | ||
| TRAM1 | 23471 | 1.32 | 0.017 | 1.10 | 0.113 | −0.50 | 0.01 | −0.49 | 0.06 |
| Genes up-regulated during 24 hrs. exposure. | |||||||||
| C3 | 718 | 1.27 | 0.075 | 1.60 | 0.011 | −0.78 | 0.00 | −0.60 | 0.02 |
| DHX15 | 1665 | 1.23 | 0.045 | 1.34 | 0.007 | −0.60 | 0.03 | ||
| ELF3 | 1999 | 1.07 | 0.446 | 1.58 | 0.006 | −0.50 | 0.01 | −0.53 | 0.05 |
| LAMC2 | 3918 | 1.03 | 0.835 | 1.34 | 0.016 | −0.75 | 0.00 | −0.50 | 0.06 |
| MMP7 | 4316 | 1.27 | 0.045 | 1.99 | 3xE-05 | −0.82 | 0.00 | −0.48 | 0.07 |
| TMEM132A | 54972 | 1.17 | 0.012 | 1.31 | 0.007 | −0.62 | 0.00 | ||
| TNFSF10 | 8743 | 1.10 | 0.299 | 1.47 | 0.007 | −0.82 | 0.00 | −0.75 | 0.00 |
| STAT1 | 6772 | 0.89 | 0.276 | 1.43 | 0.003 | −0.70 | 0.00 | −0.54 | 0.04 |
| WFDC2 | 10406 | 1.12 | 0.197 | 1.31 | 0.019 | −0.79 | 0.00 | −0.65 | 0.02 |