Figure 9. Predictive binding of curcumin, colchicine, paclitaxel and vinblastine to P. falciparum tubulin dimer.

Figures showing bound poses of curcumin diketo form at the interface of tubulin dimer. P. falciparum tubulin is represented as dimer of alpha (yellow) and beta (green) subunit. Panel A shows all the predicted bound poses, mostly at the interface of the dimer. Panel B shows the most probable binding pose according to Autodock (Rank 1) with the curcumin diketo form at the interface of alpha and beta tubulin monomers. Panel C shows binding sites of colchicine (purple), paclitaxel (red) and vinblastine (brown) on parasite tubulin dimer.