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. 2013 Mar 7;8(3):e57317. doi: 10.1371/journal.pone.0057317

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© 2013 Saussereau et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The recordings obtained with the final protocol are shown for WT (A) and cftr ^-/- B6;129 mice (B). Three phases was observed: baseline V_TE after Cl^- solution perfusion, V_TEAmil. after the addition of amiloride (Amil.) and V_TELowCl ^- after the replacement of Cl^- solution with a solution of low Cl^- concentration (LowCl^-). The inhibitory effect on Cl^- secretion of inhibitor-172 and inhibitor-172 plus DIDS was demonstrated in WT mice.