Table 2. Effects of 3 forms of thioridazine (Tz) [racemic, (+), (−)] on survival of mice challenged with Salmonella enterica serovar Typhimurium NCTC 74a.
Control group (not receiving Tz) | Test groups (receiving Tz) | |||||
Saline (ml/mouse) | No. of mice died (N = 60) | Mortality % | Tz (µg/mouse) | No.of mice died (N = 20) | % survived | |
0.1 | 52 | 86.7 | Racemic | 100 200* | 9 1 | 55 95 |
(+) | 100 200 | 12 6 | 40 70 | |||
(−) | 100 200* | 7 0 | 65 100 |
Mice received a challenge of 0.95×109 colony-forming units of S. enterica NCTC 74 in 0.5 ml of brain-heart infusion medium.
p<0.001 vs. controls (χ2 test).