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. 2013 Mar 7;8(3):e57493. doi: 10.1371/journal.pone.0057493

Table 2. Effects of 3 forms of thioridazine (Tz) [racemic, (+), (−)] on survival of mice challenged with Salmonella enterica serovar Typhimurium NCTC 74a.

Control group (not receiving Tz) Test groups (receiving Tz)
Saline (ml/mouse) No. of mice died (N = 60) Mortality % Tz (µg/mouse) No.of mice died (N = 20) % survived
0.1 52 86.7 Racemic 100 200* 9 1 55 95
(+) 100 200 12 6 40 70
(−) 100 200* 7 0 65 100
a

Mice received a challenge of 0.95×109 colony-forming units of S. enterica NCTC 74 in 0.5 ml of brain-heart infusion medium.

*

p<0.001 vs. controls (χ2 test).