Table 1. Biodistribution of 18F-CML in different organs of ICR mice.
Organ/Uptake | Intravenous administration (%ID) | Intragastric administration (%ID) | ||||
5 min | 60 min | 120 min | 5 min | 60 min | 120 min | |
Brain | 3.04±0.02 | 0.38±0.01 | 0.07±0.00 | 1.04±0.02 | 0.31±0.03 | 0.02±0.01 |
Intestines | 1.02±0.05 | 2.35±0.01 | 0.5±0.00 | 9.91±1.36 | 52.29±8.71 | 48.32±5.2 |
Stomach | 0.35±0.02 | 0.02±0.01 | 0.01±0.00 | 76.85±7.01 | 29.73±3.91 | 17.87±2.1 |
Bladder | 26.50±1.70 | 41.28±3.50 | 72.30±5.20 | 5.20±1.68 | 12.21±1.62 | 29.59±3.7 |
Lungs | 1.65±0.05 | 1.12±0.02 | 0.25±0.00 | 0.35±0.19 | 0.51±0.11 | 0.23±0.05 |
Liver | 17.28±2.04 | 9.72±1.62 | 3.28±0.05 | 1.17±0.45 | 1.0±0.12 | 0.29±0.05 |
Pancreas | 0.9±0.04 | 0.01±0.0 | 0.00±0.02 | 0.2±0.01 | 0.32±0.02 | 0.05±0.00 |
Muscles | 8.02±0.82 | 5.17±1.12 | 3.02±0.82 | 1.76±0.53 | 2.16±1.82 | 1.11±1.78 |
Kidneys | 29.30±2.05 | 35.6±4.06 | 18.1±2.65 | 2.20±0.95 | 3.31±1.91 | 2.1±0.29 |
Heart | 11.15±0.05 | 5.05±0.01 | 1.03±0.00 | 1.05±0.25 | 0.75±0.52 | 0.29±0.59 |
Radioactivity accumulation was expressed as the percentage of the injected dose per whole tissue (% ID) after a single intravenous injection or a single intragastric administration of 2 MBq of 18F-CML in 0.5 mL of saline with 2% ethanol at 3 different time points (n = 3/group, mean ± SD).