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Proposed mechanisms for formaldehyde-induced mutagenesis at the hotspot “HS3”. The three schemes summarize events catalyzed by Polζ and Polη that can generate the observed HCHO-induced, Rev3-dependent complex insertions. For simplicity the initiating DPC (indicated by the yellow star) is depicted at the guanine between the 3T and 3A runs, but other positions are possible. The base inserted opposite the initiating DPC is in red.
