Table 3.
Types and number of HCHO-induced events at the TTTCAAA hotpsot
| New sequence at hotspot | Number of events observeda |
||||
|---|---|---|---|---|---|
| Type | [mutations] | WT | rad14 | rad14 rad30 | rad14 rev3 |
| 1 | TTTCAAAA | 1 | 19 | 5 | 0 |
| [3A > 4A] | (P=0.014) | (P<0.001) | |||
| 2 | TTTTAAAA | 0 | 14 | 0 | 0 |
| [C > T, 3A > 4A or C > A, 3T >4T] | (P<0.001) | (P<0.001) | |||
| 3 | TTTAAAAA | 0 | 10 | 6 | 0 |
| [C > A and 3A > 4A] | (P=0.41) | (P=0.003) | |||
| Other complex | 0 | 2 | 5 | 1 | |
| Total mutants sequenced | 137 | 147 | 113 | 112 | |
a
P values were obtained using the Fisher Exact test to compare the numbers of a given event in the rad14 single and indicated double mutants.