TABLE 1.
Fxyd2−/− mouse colony breeding history
Each generation (i.e. each row) comprises all of the pairs or harems bred in a backcross or intercross generation. The breeding success data are broken down into three categories: how many visible pregnancies were observed per month, how many of the litters that were born had any surviving pups, and of successful litters, what percentage of pups survived to weaning. The numbers for the mutant mice represent the most optimistic values, because the % survival of pups did not take into account any pups that died and were eaten before they were detected and counted.
| Breeding partners, genotype | Pregnancies/month. The average for each generation is listed separately. n = number of pregnancies | % Successful litters where any pups survived | % Survival of pups, in litters where any pups survived |
|---|---|---|---|
| Back-cross, | 1.0 (n = 2) | 50 | 87 |
| Fxyd2−/− sire, and | 1.0 (n = 7) | 100 | 87 |
| WT dam | 0.84 (n = 8) | 100 | 89 |
| Back-cross, | 1.0 (n = 12) | 100 | 85 |
| Fxyd2+/− sire, and WT dam | 1.3 (n = 6) | 83 | 85 |
| Back-cross, | 0.4 (n = 4) | 100 | 100 |
| WT sire, and | 0.5 (n = 12) | 42 | 74 |
| Fxyd2−/− dam | |||
| Fxyd2+/− sire | 0.43 (n = 37) | 65 | 82 |
| Fxyd2+/− dam | 0.57 (n = 33) | 66 | 70 |
| 0.3 (n = 16) | 75 | 82 | |
| 0.4 (n = 12) | 75 | 100 | |
| 0.56 (n = 13) | 77 | 98 | |
| 0.92 (n = 23) | 96 | 82 | |
| 0.64 (n = 12) | 75 | 64 | |
| Fxyd2−/− sire | 0.54 (n = 4) | 50a | 50a |
| Fxyd2−/− dam | 0.83 (n = 3) | 33 | 6 |
| 0.46 (n = 2) | 50 | 50 | |
| 0.87 (n = 3) | 66a | 54a |
a Some newborn pups were fostered with WT dams (synchronized pregnancies).