Table I. Selection analyses of snake venom metalloproteinase (SVMP) propeptides. ω: mean dN/dS.

	SLACa	FELb	RELc	Integrative analyses	MEMEd	PAMLg
				SLAC + FEL + REL + MEME		M8	M2a
Psammophis
ω > 1e	0	1	0	2		2	1
Monodomain
ω < 1f	1	2	4	4	1	(0 + 2)	(0 + 1)
SVMP
ω =	0.95	-	2.51	-		1.23	1.24
Echis
ω > 1e	0	0	2	2		0	0
Monodomain
ω < 1f	0	4	1	5	0
SVMP
ω =	0.32	-	0.43	-		0.52	0.52
Echis
ω > 1e	0	1	2	3		0	0
Multidomain
ω < 1f	5	12	0	12	1
SVMP
ω =	0.47	-	0.82	-		0.46	0.46

^a Single Likelihood Ancestor Counting.

^b Fixed-effects likelihood.

^c Random-effects likelihood.

^d Sites detected as experiencing episodic diversifying selection (0.05 significance) by the Mixed Effects Model Evolution (MEME).

^e Number of positively selected sites at 0.05 significance (for SLAC, FEL) or 50 Bayes factor (for REL).

^f Number of negatively selected sites at 0.05 significance (for SLAC, FEL) or 50 Bayes factor (for REL).

^g Positively selected sites detected using the Bayes Empirical Bayes approach implemented in the site models (M8 and M2a). Sites detected at 0.99 and 0.95 significance are indicated in the parenthesis.