Table II. Selection analyses of Echis coloratus snake venom metalloproteinase (SVMP) domains. ω: mean dN/dS.

	SLACa	FELb	RELc	Integrative	MEMEd	PAMLg
				SLAC + FEL + REL + MEME		M8	M2a	Option Gh
Propeptide
ω > 1e	0	1	0	2		0	0
ω < 1f	1	2	4	4	1			0.38
ω =	0.95	-	2.51	-		0.46	0.46
Peptidase M12B
ω > 1e	0	1	8	8		28	15
ω < 1f	2	8	7	10	0	(14 + 14)	(5 + 10)	1.28
ω =	0.83	-	-	-		1.60	1.60
Disintegrin
ω > 1e	0	1	3	3		9	6
ω < 1f	2	7	9	10	0	(4 + 5)	(3 + 3)	0.91
ω =	0.87	-	-	-		1.33	1.35
Cysteine-rich domain
ω > 1e	0	2	5	10		15	8
ω < 1f	2	8	16	18	7	(6 + 9)	(4 + 4)	1.04
ω =	1.04	-	-	-		1.44	1.43
Entire toxin
ω > 1e	1	8	7	33		34	27
ω < 1f	14	33	15	34	28	(14 + 20)	(9 + 18)	-
ω =	1.02	-	2.49	-		1.15	1.16

^a Single Likelihood Ancestor Counting.

^b Fixed-effects likelihood.

^c Random-effects likelihood.

^d Sites detected as experiencing episodic diversifying selection (0.05 significance) by the Mixed Effects Model Evolution (MEME).

^e Number of positively selected sites at 0.05 significance (for SLAC, FEL) or 50 Bayes factor (for REL).

^f Number of negatively selected sites at 0.05 significance (for SLAC, FEL) or 50 Bayes factor (for REL).

^g Positively-selected sites detected using the Bayes Empirical Bayes approach implemented in the site models (M8 and M2a). Sites detected at 0.99 and 0.95 significance are indicated in the parenthesis.

^h Mean dN/dS computed using Mgene and option G.