Table 1.
Baseline characteristics of study participants
| Characteristic | Alendronate | Zoledronate | Reference |
P values |
||
|---|---|---|---|---|---|---|
| A | B | C | ||||
| Sample size (n) | 43 | 41 | 27 | |||
| Heart transplant | 26 (60) | 27 (66) | 17 (63) | |||
| Liver transplant | 17 (40) | 14 (34) | 10 (37) | |||
| Days from transplantation to randomization | 26 ± 7 | 27 ± 9 | NA | 0.65 | ||
| Age (yr) | 54 ± 10 | 55 ± 8 | 48 ± 15 | 0.41 | 0.03 | 0.08 |
| Gender | ||||||
| Male | 35 (81) | 30 (73) | 20 (74) | 0.37 | 0.94 | 0.47 |
| Female | 8 (19) | 11 (27) | 7 (26) | |||
| Postmenopausal | 6 (75) | 10 (91) | 3 (43) | 0.86 | 0.09 | 0.51 |
| Race/ethnic group | ||||||
| Non-Hispanic White | 27 (63) | 31 (76) | 19 (70) | 0.10 | 0.76 | 0.79 |
| Non-Hispanic Black | 4 (9) | 6 (15) | 3 (11) | |||
| Hispanic | 12 (28) | 4 (9) | 5 (19) | |||
| Cardiac diagnosis | ||||||
| Dilated | 13 (50.0) | 14 (51.9) | 11 (64.7) | 1.00 | 0.73 | 0.38 |
| Ischemic | 9 (34.6) | 9 (33.3) | 3 (17.6) | |||
| Congenital | 0 (0) | 1 (3.7) | 1 (5.9) | |||
| Other | 4 (15.4) | 3 (11.1) | 2 (11.8) | |||
| Liver diagnosis | ||||||
| Cholestatic | 1 (5.9) | 1 (7.2) | 1 (10.0) | 0.42 | 0.41 | 0.78 |
| Viral | 11 (64.7) | 6 (42.8) | 8 (80.0) | |||
| Alcohol | 3 (17.6) | 1 (7.2) | 0 (0) | |||
| Other liver disease | 1 (5.9) | 3 (21.4) | 1 (10.0) | |||
| Viral and alcohol | 1 (5.9) | 3 (21.4) | 0 (0) | |||
| BMD (g/cm2) | ||||||
| Lumbar spine | 0.976 ± 0.167 | 0.947 ± 0.113 | 1.111 ± 0.143 | 0.37 | <0.001 | <0.001 |
| T score | −1.1 ± 1.5 | −1.3 ± 1.0 | 0.1 ± 1.3 | 0.37 | <0.001 | <0.001 |
| Z score | −0.5 ± 1.6 | −0.6 ± 1.0 | 0.6 ± 1.4 | 0.69 | <0.001 | 0.01 |
| Femoral neck | 0.790 ± 0.120 | 0.742 ± 0.113 | 0.912 ± 0.113 | 0.07 | <0.001 | <0.001 |
| T score | −1.1 ± 0.8 | −1.4 ± 0.8 | −0.1 ± 0.9 | 0.08 | <0.001 | <0.001 |
| Z score | −0.3 ± 0.9 | −0.5 ± 0.7 | 0.5 ± 0.8 | 0.18 | <0.001 | 0.01 |
| Total hip | 0.941 ± 0.136 | 0.904 ± 0.133 | 1.064 ± 0.122 | 0.22 | <0.001 | <0.001 |
| T score | −0.6 ± 0.8 | −0.9 ± 0.8 | 0.3 ± 0.8 | 0.23 | <0.001 | <0.001 |
| Z score | −0.2 ± 0.9 | −0.4 ± 0.8 | 0.6 ± 0.8 | 0.43 | <0.001 | 0.01 |
Data are expressed as mean ± sd or number (percentage). NA, Not applicable. P values: A, Alendronate vs. zoledronate; B, zoledronate vs. reference; C, Alendronate vs. reference.