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. 2012 Oct 22;591(Pt 4):823–833. doi: 10.1113/jphysiol.2012.242016

Figure 1. GABA transporter currents.

Figure 1

A, left, DIC image of an astrocyte (white arrow) in the VB thalamus with the recording patch electrode visible on the right hand side of the picture (scale bar, 10 μm). Right, current responses to 10 mV voltage steps from the imaged astrocyte. B, left current trace illustrates the typical response of a thalamic astrocytes to focal application of 100 μl aCSF without (aCSF) and with 10 mm GABA (GABA). The current trace to the right illustrates the response of the same astrocyte to a second focal application of GABA a few minutes after the one shown on the left. C, properties of GABA transporter currents in NEC and GAERS. D, GABA transporter currents in control condition (CTRL) and during application of GAT-1 (NO711, 30 μm) and GAT-3 (SNAP5114, 60 μm) blockers. Top and bottom panels show representative currents from NECs and GAERS, respectively. E, amplitude and charge transfer (Q) of the GABA transporter currents in NEC (n = 6) and GAERS (n = 7) expressed as % of those under control conditions. * Indicates significance for each group against control conditions (*P < 0.05, **P < 0.01 or ***P < 0.005); † indicates significant difference (P < 0.05) between NEC and GAERS.