Figure 4. GABA_B1b-containing receptors are necessary for afferent-evoked termination of the UP state.

A, representative traces taken from wild-type (WT), GABA_B1a^−/− and GABA_B1b^−/− mice. Three trials taken from the same neuron are presented for each condition. B, layer 1 stimulation shortened the UP state in wild-type and GABA_B1a^−/− mice but not in GABA_B1b^−/− mice. C, the selective GABA_B receptor antagonist CGP55845 (1 μm) prevented layer 1 stimulation from shortening the UP state. Error bars are SEM. ***P < 0.001; paired t test.