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. 2012 Nov 5;591(Pt 4):899–918. doi: 10.1113/jphysiol.2012.242180

Figure 6. Effects of glutamate receptor blockers on the early- and late-onset response.

Figure 6

A, post-synaptic responses evoked by a train of 10 pulses to the MFB in a UBC showing both the early- and the late-onset response, in control condition (top trace) and after perfusion of APV plus NBQX in the bath (bottom trace). Note that the early-onset response was blocked by the NMDA/AMPA receptor antagonists, thus unmasking the late-onset response. The inset shows the stimulus region in greater detail, demonstrating abolition of EPSPs following drug perfusion. B, post-synaptic responses evoked by a train of 10 pulses to the MFB in a UBC showing only the late-onset response, in control condition (top trace) and after perfusion of MCPG in the bath (bottom trace). Note the lack of effect of MCPG.