Table 2.
AHP parameters following single APs or a train of APs
| Cell type | Control | SNL4 | SNL5 | Injury effect P | ||
|---|---|---|---|---|---|---|
| n | Ai | 55 | 26 | 41 | ||
| Ao | 91 | 44 | 28 | |||
| AHPamp | Ai | Single (mV) | 12.8[8.8/15.3] | 12.7[7.9/15.9] | 8.4[6.7/10.7]* | 0.002 |
| 20th (mV) | 10.5[6.3/13.4]§§ | 9.0[5.3/12.5]§§ | 6.1[4.0/8.3]§§* | 0.002 | ||
| Δ (%) | −17.7[−5.1/−29.7] | −24.5[−14.7/−28.7] | −28.7[−12.6/−48.7] | 0.55 | ||
| Ao | Single (mV) | 12.5 [8.9/15.0] | 13.0 [9.6/14.7] | 8.8 [6.9/11.6] | 0.038 | |
| 20th (mV) | 9.1 [4.5/10.9]§§ | 9.6[6.6/11.4]§§ | 7.4 [4.8/11.0] | 0.34 | ||
| Δ (%) | −26.6[−12.8/−49.8] | −24.1[−7.1/−39.7] | −8.7[−2.6/−24.3]* | 0.014 | ||
| AHPd | Ai | Single (ms) | 29.8[12.2/45.5] | 27.7 [17.1/38.4] | 7.6 [4.8/13.3]**†† | <0.001 |
| 20th (ms) | 129.0[45.5/215.5] | 168.0[72.3/309.5]§ | 46.5[11.0/138.5]**† | <0.01 | ||
| Δ (%) | 300[83/690] | 358[197/856] | 309[44/1015]† | 0.02 | ||
| Ao | Single (ms) | 7.2[4.2/12.3] | 5.9 [4.0/12.4] | 8.4[5.5/19.6] | 0.75 | |
| 20th (ms) | 61.0[17.3/117.4]§§ | 36.1[14.0/93.5]§§ | 50.4[21.7/99.0]§§ | 0.38 | ||
| Δ (%) | 476[115/1342] | 299[120/1114] | 369[144/1158] | 0.44 | ||
| AHParea | Ai | Single (ms mV) | 363 [176/552] | 294 [172/519] | 62 [33/131]**†† | <0.001 |
| 20th (ms mV) | 1211[580/2112]§§ | 993[369/1936] | 87 [−25/418]**† | <0.001 | ||
| Δ (%) | −241[−81/475] | −194[−24/−485] | −50[−580/147]** | <0.001 | ||
| Ao | Single (ms mV) | 75 [39/154] | 88 [52/151] | 51 [29/141] | 0.23 | |
| 20th (ms mV) | 77[119/1159]§§ | 453[196/920]§§ | 624[145/1523]§§ | 0.54 | ||
| Δ (%) | −364[−98/−759] | −351[−87/−680] | −609[−113/−1209] | 0.38 |
Values are expressed as median [25th/75th percentile]. Amplitude and area hyperpolarized compared with the RMP are considered positive. Injury effect P indicates the ANOVA main effect of injury for the parameter in that row. For post hoc comparisons: different from Control *P < 0.05, **P < 0.01; different from SNL4 †P < 0.05, ††P < 0.01; 20th different from single §P < 0.05, §§P < 0.01. AHPamp, afterhyperpolarization amplitude; AHParea, area of the afterhyperpolarization; AHPd, afterhyperpolarizarion duration; n, number of cells; SNL, spinal nerve ligation; SNL4, 4th lumbar ganglion after SNL; SNL5, 5th lumbar ganglion after SNL.