Table 1.

Comparison of membrane properties and network activity in R6/2 WT and CAR mice

	WT			CAR
Property	Mean	±SEM	n	Mean	±SEM	n	p value	Test
Membrane potential (mV)	−69.5	0.58	108	−60.5	0.96	101	<0.0001	Mann-Whitney’s U test
Whole-cell input resistance (MΩ)
Intracellular standard	59.2	2.50	107	128.2	8.44	99	<0.0001	Mann-Whitney’s U test
Intracellular with GDPβS	38.1	3.10	13	72.70	4.80	37	<0.0010	Student's unpaired t test
Whole-cell capacitance (pF)	79.7	1.91	107	66.1	1.63	99	<0.0001	Student's unpaired t test
Reobasic current (pA)	189.6	11.66	71	97.3	6.14	66	<0.0001	Mann-Whitney’s U test

All measurements at a holding voltage V_h=−70 mV and chloride reversal potential E_Cl=−21 mV. The age of the R6/2 cohort was 78.0 ± 1.1 days, n= 91 vs. CAR 75.0 ± 1.2 days, n= 77 (n.s.). Abbreviations: n, number of neurons; p value, significance level; for all other abbreviations see list on Introduction page.