Table 2.

GABAergic synaptic transmission in R6/2 WT and CAR

	WT			CAR
Property	Mean	±SEM	n	Mean	±SEM	n	p value	Test
Basic characteristics (all connections)
Mean eIPSC amplitude (pA)	170.74	10.81	108	116.29	6.80	101	<0.0001	Mann-Whitney’s U test
Maximal eIPSC amplitude (pA)	293.17	16.68	99	201.07	9.60	93	<0.0001	Mann-Whitney’s U test
P (mean eIPSC/maximal eIPSC)	0.58	0.01	99	0.53	0.01	93	0.0076	Student's unpaired t test
eIPSC failure rate (%)	3.13	0.46	108	6.95	0.97	101	0.0228	Mann-Whitney’s U test
eIPSC CV (coefficient of variation, %)	35.66	1.18	107	41.54	1.78	101	0.0059	Student's unpaired t test
Asyncronicity index (100 Hz test)	0.96	0.16	18	2.41	0.35	16	0.0004	Student's unpaired t test
dIPSC integral (pA s)	4.64	0.65	18	9.64	2.02	16	0.0192	Student's unpaired t test
PPR (eEPSC2/eEPSC1)	0.71	0.01	108	0.81	0.02	101	<0.0001	Student's unpaired t test
PPR % change by CB1 block	None	—	14	−7.50	3.00	9	0.0432	Student's paired t test
PPR % change by GABAB receptor block	−7.55	2.19	14	None	—	14	0.0195	Student's paired t test
Quantal analysis (based on 100 Hz test)
Q (median of dIPSC distribution; pA)	29.46	3.03	18	35.08	1.69	16	0.1273	Student's unpaired t test
N (RRP = cumulative eIPSC at time 0/Q)	19.39	2.69	18	14.79	2.32	16	0.2113	Student's unpaired t test
Pves (mean eIPSC/Q)	0.41	0.03	18	0.32	0.02	16	0.0252	Student's unpaired t test
m (mean eIPSC/Q)	7.04	0.65	18	4.41	0.61	16	0.0062	Student's unpaired t test

All measurements were made at V_h=−70 mV and E_Cl=−21 mV. The recording electrode contained, among other constiuents, 100 mm potassium gluconate and 50 mM KCl. n, number of neurons; p value, significance level; P, probability of release. For other abbreviations see list on Introduction page.