Table 1.
Association between ADAMTS7 rs3825807 and Carotid Atherosclerosis in the Bruneck Study
|
Age/Sex-Adjusted Model |
Multivariable Modelb |
|||
|---|---|---|---|---|
| OR (95% CI)a | p value | OR (95% CI)a | p value | |
| Presence of atherosclerosis in 1990 | 0.58 (0.35–0.96) | 0.035 | 0.51 (0.31–0.84) | 0.008 |
| Presence of atherosclerosis in 1995 | 0.51 (0.32–0.82) | 0.005 | 0.53 (0.31–0.90) | 0.019 |
| Incident atherosclerosis in 1990–1995 | 0.69 (0.43–1.10) | 0.121 | 0.67 (0.40–1.09) | 0.108 |
| β (95% CI)a | p value | β (95% CI)a | p value | |
| Atherosclerosis score in 1990 | −0.43 (−0.77, −0.09) | 0.013 | −0.45 (−0.78, −0.11) | 0.010 |
| Atherosclerosis score in 1995 | −0.53 (−0.89, −0.16) | 0.005 | −0.50 (−0.86, −0.14) | 0.006 |
| Carotid intima-media thickness in 1995 | −0.02 (−0.06–0.02) | 0.427 | −0.02 (−0.06–0.02) | 0.401 |
a
Odds ratios (OR) and regression coefficients (β) were derived from logistic and linear regression analyses respectively, comparing the G/G genotype versus the A/A and A/G genotypes.
b
Multivariable analyses were performed with adjustment for variables correlated with atherosclerosis parameters in the Bruneck cohort, as described in Subjects and Methods.