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In vivo time course of antibacterial activity of vancomycin at 3.125, 12.5, 50, and 200 mg/kg, administered s.c. every 6 h at both low (solid circles) and high (solid triangles) inocula of MRSA 19931 (Fig. 2A) and MRSA 11888 (Fig. 2B) injected into opposite thighs of neutropenic mice. Open circles and triangles represent the growth in saline-treated controls.
