Table 1.
In vitro activity of antimicrobials against strains of S. aureus and S. pneumoniae
| Organisma | MIC (mg/liter) |
|||||
|---|---|---|---|---|---|---|
| Ceftobiprole | Daptomycin | Linezolid | Vancomycin | Oxacillin | Penicillin | |
| S. aureus strains | ||||||
| ATCC 29213 (MSSA) | 0.5 | 0.5 | 2 | 1.0 | 0.12 | |
| SMITH (MSSA) | 0.5 | 0.25 | 4 | 0.5 | 0.06 | |
| 22115 (MRSA) | 1 | 0.25 | 2 | 1.0 | >64 | |
| 18000 (MRSA) | 1 | 0.25 | 2 | 0.5 | 16 | |
| 12248 (MRSA) | 2 | 0.12 | 2 | 0.5 | 64 | |
| 11888 (MRSA) | 2 | 0.25 | 1 | 0.5 | >64 | |
| 19936 (MRSA) | 0.5 | >64 | ||||
| 21773 (hVISA) | 0.5 | 64 | ||||
| 20594 (hVISA) | 0.5 | >64 | ||||
| S. pneumoniae strains | ||||||
| ATCC 10813 (PSSP) | 0.03 | 0.12 | 1 | 0.12 | < 0.008 | |
| MNO-418 (PSSP) | 0.015 | 0.25 | 0.5 | 0.12 | < 0.008 | |
| CDC 1293 (PRSP) | 0.5 | 0.25 | 0.5 | 0.25 | 2.0 | |
| CDC 1329 (PRSP) | 0.25 | 0.12 | 0.25 | 0.12 | 2.0 | |
a
Abbreviations: MSSA, methicillin-susceptible S. aureus; MRSA, methicillin-resistant S. aureus; hVISA, heteroresistant vancomycin-intermediate S. aureus; PSSP, penicillin-susceptible S. pneumoniae; PRSP, penicillin-resistant S. pneumoniae.