Table 3.

Inoculum effect and index for each drug and each organism^a

Organism	Static dose (mg/kg/day) and IE index with:
	Ceftobiprole			Daptomycin			Linezolid			Vancomycin
	LI	HI	IE index	LI	HI	IE index	LI	HI	IE index	LI	HI	IE index
MSSA
29213	2.54	11.8	4.6	20.8	53.6	2.6	100	323	3.2	34.4	243	7.1
SMITH	4.51	8.55	1.9	5.61	13.6	2.4	63.1	316	5.0	12.1	75.8	6.3
MRSA
22115	15.3	57.0	3.7	6.25	14.1	2.3	56.5	222	3.9	16.9	125	7.4
18000	4.41	7.50	1.7	2.49	11.3	4.5	51.7	212	4.3	7.52	112	14.9
12248	50.3	97.5	1.9	2.93	10.4	3.6	94.2	162	1.7	9.40	95.8	10.2
11888	40.0	149	3.7	1.70	15.8	9.3	8.81	62.5	7.1	12.7	258	20.3
19936										6.01	66.4	11.0
21773										13.9	92.4	6.6
20594										8.16	58.4	7.2
S. aureus (mean ± SD)			2.9 ± 1.2			4.1 ± 2.7			4.6 ± 2.3			10.1 ± 4.7b
PSSP
10813	0.182	0.237	1.3	0.304	0.553	1.8	29.8	65.4	2.2	1.10	3.48	3.2
MNO-418	0.134	0.358	2.7	1.02	2.01	2.0	28.3	48.2	1.7	2.95	3.45	1.2
PRSP
CDC 1293	4.04	11.1	2.7	2.08	5.77	2.8	17.3	34.7	2.0	8.07	6.08	0.8
CDC 1329	2.56	8.37	3.3	0.551	0.890	1.6	9.30	17.0	1.8	2.52	2.37	0.9
S. pneumoniae (mean ± SD)			2.5 ± 0.8			2.0 ± 0.5			1.9 ± 0.2c			1.5 ± 1.1c

^aAbbreviations: LI, low inoculum; HI, high inoculum; IE, inoculum effect; MSSA, methicillin-susceptible S. aureus; MRSA, methicillin-resistant S. aureus; PSSP, penicillin-susceptible S. pneumoniae; PRSP, penicillin-resistant S. pneumoniae; SD, standard deviation.

^bStatistically different from the IE indexes of ceftobiprole, daptomycin, and linezolid against Staphylococcus aureus (P < 0.05).

^cStatistically less for S. pneumoniae than for S. aureus (P < 0.05).