. 2013 Mar;57(3):1505–1508. doi: 10.1128/AAC.01766-12

Table 1.

Antiviral activity and thermodynamic and kinetic effects of HAP12, HAP13, and AT-130

Assembly effector	EC₅₀ (μM) (mean ± SEM)	ΔΔG_cont (kcal/mol) (mean ± SEM)	K_index^a (mean ± SEM)
HAP12^b	0.012 ± 0.002	−1.92 ± 0.07	−3.69 ± 0.05
AT-130^c	2.40 ± 0.92	−0.99 ± 0.18	−2.08 ± 0.07
HAP13^b	6.10 ± 0.50	−0.69 ± 0.11	−2.41 ± 0.03

The kinetic index was determined by light scattering experiments as follows: K_index = −log(slope/concentration of assembly effector), where slope is the steepest slope of the light scattering (LS) trace in arbitrary units, and the assembly effector concentration is micromolar.

Data for HAP12 and HAP13 assembly energetics and EC₅₀ are from reference 17. EC₅₀ was the concentration of the compound required to reduce the concentration of HBV DNA produced in HepG2.2.15 cell culture medium by 50%. DNA concentrations were determined by quantitative Southern blotting.

Data for AT-130 EC₅₀ are from reference 7, where the term 50% inhibitory concentration (IC₅₀) was used to describe results from the same assay as in footnote b. Data for AT-130 assembly energetics are from reference 3.