Table 2.
Percentage of infected macrophages and relative intracellular amastigote survival with treatmenta
| Treatment | Time after treatment (h) | % Mpb (mean ± SD) | % Pc (mean ± SD) |
|---|---|---|---|
| Amphotericin B (0.5 μM) | 24 | 19 ± 11.50 | 5.1 ± 4.6 |
| 48 | 5 ± 5.34 | 1 ± 1 | |
| 72 | 0 ± 0.58 | 0 | |
| HePC (7 μM) | 24 | 94 ± 5.13 | 66.9 ± 32.2 |
| 48 | 84 ± 6.11 | 45.1 ± 14.2 | |
| 72 | 85 ± 2.08 | 60.0 ± 18.3 | |
| Staurosporine (0.2 μM) | 24 | 99 ± 0.58 | 97.2 ± 8.7 |
| 48 | 99 ± 1.15 | 51.5 ± 12.9 | |
| 72 | 96 ± 7.51 | 47.4 ± 20.9 |
a
Data are normalized to the values obtained for untreated (HePC) or 0.5% DMSO-treated controls at the respective time point (set to 100%).
b
% Mp, percentage of infected macrophages.
c
% P, relative intracellular amastigote survival (number of parasites/100 macrophages).