Table 3.
IC50s for azole antifungal agents with CaCYP51 and Δ60HsCYP51
| Azole antifungal agent | IC50 (μM) |
|
|---|---|---|
| CaCYP51 | Δ60HsCYP51 | |
| Medical azoles | ||
| Fluconazole | 0.6 | ∼1,300a |
| Itraconazole | 0.4 | 70 |
| Ketoconazole | 0.5 | 4.5 |
| Agricultural azoles | ||
| Epoxiconazole | 0.5 | 12 |
| Prochloraz | 0.7 | 8 |
| Propiconazole | 0.6 | 110 |
| Prothioconazole | 150 | Noneb |
| Prothioconazole-desthio | 0.6 | 100 |
| Tebuconazole | 0.9 | 1.3 |
| Triadimenol | 1.3 | 30 |
a
Only 25% inhibition of Δ60HsCYP51 activity occurred in the presence of 653 μM fluconazole. The estimated IC50 for fluconazole is greater than 1,300 μM.
b
No significant inhibition of Δ60HsCYP51 activity occurred in the presence of 290 μM prothioconazole.