Table 4.

Plasma accumulation values (day 3 AUC_0–24 vs day 1 AUC_0–24) for GS-9851, GS-566500, and GS-331007

Analyte	GS-9851 treatment (mg)	Accumulation, GLSMa			90% CI
		Test	Reference	Ratio
GS-9851	Overall	74.99	79.44	0.94	0.63, 1.41
	50	26.45	38.60	0.69	0.33, 1.41
	100	73.46	46.96	1.56	0. 53, 4.63
	200	114.65	115.14	1.00	0.48, 2.08
	400	141.93	190.80	0.74	0.34, 1.62
GS-566500	Overall	51.40	68.16	0.75	0.45, 1.28
	50	17.98	16.86	1.07	0.40, 2.83
	100	49.08	74.12	0.66	0.21, 2.13
	200	57.13	83.44	0.68	0.22, 2.17
	400	138.44	206.94	0.67	0.25, 1.82
GS-331007	Overall	1,909.48	1,584.03	1.21	1.01, 1.45
	50	851.38	863.61	0.99	0.61, 1.60
	100	1,685.25	1,136.42	1.48	1.03, 2.13
	200	2,797.72	2,418.59	1.16	0.85, 1.57
	400	3,311.80	2,652.34	1.25	0.86, 1.81

^aGeometric least-squares mean.