Table 2.

Intracellular concentrations of AZT-TP or DXG-TP for activated or resting macrophages or PBM cells treated with 10 μM AZT-DXG at a ratio of 1:1^a

Cell type	Drugb	Active metabolite measured	Intracellular NRTI-TP(±SD)
			μM	pmol/106 cells
PBM cells
Activated	AZT	AZT-TP	3.5 ± 0.9	1.1 ± 0.3
Activated	AZT + DXG	AZT-TP	2.7 ± 0.6	0.9 ± 0.2
Activated	DXG	DXG-TP	0.2 ± 0.1	0.06 ± 0.03
Activated	AZT + DXG	DXG-TP	0.25 ± 0.01	0.1 ± 0.003
Resting	AZT	AZT-TP	1.8 ± 0.4	0.6 ± 0.1
Resting	AZT + DXG	AZT-TP	1.4 ± 0.3	0.5 ± 0.1
Resting	DXG	DXG-TP	0.5 ± 0.2	0.2 ± 0.06
Resting	AZT + DXG	DXG-TP	0.54 ± 0.12	0.2 ± 0.03
Macrophages
Activated	AZT	AZT-TP	0.3 ± 0.3	0.8 ± 0.8
Activated	AZT + DXG	AZT-TP	0.1 ± 0.05	0.3 ± 0.1
Activated	DXG	DXG-TP	0.05 ± 0.04	0.1 ± 0.1
Activated	AZT + DXG	DXG-TP	0.02 ± 0.008	0.05 ± 0.02
Resting	AZT	AZT-TP	0.1 ± 0.1	0.3 ± 0.3
Resting	AZT + DXG	AZT-TP	0.1 ± 0.01	0.3 ± 0.03
Resting	DXG	DXG-TP	0.04 ± 0.03	0.1 ± 0.08
Resting	AZT + DXG	DXG-TP	0.02 ± 0.01	0.05 ± 0.03

^aThe presence of AZT did not antagonize DXG-TP levels in macrophages or PBM cells, independent of the activation state, and the presence of DXG did not antagonize AZT-TP levels in macrophages or PBM cells independent of the activation state.

^bAZT + DXG at a ratio of 1:1.