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Effect of C3 on TNF-α- or Tat-induced HIV-1 LTR transactivationa
| Cell type | Tat | TNF-α | EC50b (nM) | CC50c (nM) |
|---|---|---|---|---|
| W-3 | + | − | 183 ± 50 | >2,000 |
| − | + | >2,000 | >2,000 | |
| KM-3 | + | − | 107 ± 11 | >2,000 |
| − | + | >2,000 | >2,000 |
All data represent means ± standard deviations for three separate experiments.
EC50, 50% effective concentration, i.e., concentration that inhibits SEAP activity in culture supernatants by 50%.
The CC50 reduces the cell viability by 50%.
