Table 1.
Animal experimental protocola
| Group | Treatment on the indicated day(s) for the following: |
|||
|---|---|---|---|---|
| Prevention groups |
Therapy groups |
|||
| 1–7 | 8 | 1 | 1–2 | |
| Control (n = 10) | SM | PW | PW | SM |
| Cd only (n = 15) | SM | Cd | Cd | SM |
| Cd + living 8610 (n = 10) | SM + living 8610 | Cd | Cd | SM + living 8610 |
| Cd + dead 8610 (n = 10) | SM + dead 8610 | Cd | Cd | SM + dead 8610 |
a
PW, a single oral dose of 0.5 ml plain water; SM, a single oral dose of 0.5 ml skim milk; Cd, a single oral dose of cadmium chloride in 0.5 ml plain water at 1.8 mg Cd each mouse; SM + living 8610, living L. plantarum CCFM8610 at 1 × 109 CFU with 0.5 ml skim milk once daily; SM + dead 8610, dead L. plantarum CCFM8610 with 0.5 ml skim milk once daily. Animals received plain water, skim milk, Cd, and CCFM8610 via gavage. Mice were fasted for 12 h before cadmium exposure. In the therapy groups, skim milk and lactobacilli were administered 1 h after cadmium exposure.