Fig 10.

Cross-coordination of different antibiotic biosynthetic pathways by the pseudo-GBL receptors in S. venezuelae. The pseudo-gamma-butyrolactone receptor JadR2 directly represses the transcription of jadR1 in the absence of ethanol and also binds chloramphenicol (Cm) and jadomycins. The cluster-situated regulator JadR1 activates the biosynthesis of jadomycin B by activating the transcription of biosynthetic structural genes. JadR1 also represses the production of Cm by binding to the promoters of the structural genes (51).