Fig 1.

Phylogeny of the predicted ROK family proteins of S. coelicolor M145 and alignment of Cys motifs. (A) Phylogram of the ROK proteins of S. coelicolor based on ClustalW analysis (46). ROK-family proteins containing a conserved zinc binding motif are marked by asterisks. The names of proteins along with known or suspected functions are given. (B) Alignment of the partial amino acid sequences of the ROK-family proteins that contain the zinc binding motif, with B. subtilis XylR and E. coli NagC included for reference purposes. Asterisks refer to the conserved Cys and His residues that coordinate the zinc atom. For shading, at least 50% of the aligned proteins should share the same or similar amino acid residues. Identical residues are shaded black, similar residues are shaded gray.