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CFU-e numbers are reduced in SclΔ40/Δ40 bone marrow (BM) and spleen (S). (A to D) Histograms showing numbers of CFU-GM (A), CFU-MK(B), CFU-e (C), and BFU-e (D) in bone marrow and spleen. *, P ≤ 0.05; **, P ≤ 0.01. (E) Histogram showing percentages of hematopoietic stem and progenitor cells in lineage-negative bone marrow cells. (F) Relative expression of Scl in early stem and progenitor cells. (G) Relative expression of Scl in Lin− Sca1+ Kit+ cells. WT, SclWT/WT; KO, SclΔ40/Δ40.
