Fig 3.

Soluble heparin inhibits EBOV GP-mediated infection of human primary umbilical vein endothelial cells (A), human fetal liver cells (B), and human macrophages (C), which represent main targets of filovirus natural infection. The cells were infected with concentrated HIV pseudotypes bearing the different filovirus envelope glycoproteins in the presence or absence of different concentrations of soluble heparin (μg/ml). Results are expressed as relative light units (RLU) and represent the means ± SD for duplicate wells. The results are representative of at least two different experiments. Statistics consisted of one-way ANOVA followed by Bonferroni posttests. *, P < 0.05; **, P < 0.01; ***, P < 0.001.