Fig 7.

Regulation of IFN-β and IFN-λ production in mTECs. mTEC cultures were derived from wild-type, IFNAR^−/−, and Stat1^−/− mice. The cells were stimulated with poly(I·C) (left panels) and influenza virus (right panels) as described in Materials and Methods, and the concentrations of IFNs were measured by ELISA 24 h later. (A) IFN-λ in response to poly(I·C); (B) IFN-λ in response to influenza virus; (C) IFN-β in response to poly(I·C); (D) IFN-β in response to influenza virus. The data are representative of two independent experiments with three samples per group (means and SD). *, P ≤ 0.05; **, P ≤ 0.005.