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Determination of antibody-driven escape mutants. (A) Antibody-driven escape mutants were generated through a series of passages. (B) Point mutations found in two 100F4 antibody-driven escape clones compared to the sequence of parental H5 HA. (C) Sequence alignment of amino acid residues 65 to 75 and 110 to 119 among 21 HA covering all H5 clades and subclades. Residues 68 and 112 are highlighted in boxes.
