Fig. 4 a.

Plasma deficient in coagulation factor VIII produces a loose, porous clot that is readily subject to fibrinolysis; b addition of rFVIIa, 1.9 µg/ml, a concentration equivalent to that achieved with exogenous administration of approximately 90–100 µg/kg rFVIIa, to plasma deficient in coagulation factor VIII restores the fibrin clot to a tight, normal architecture, resistant to fibrinolysis. Reproduced with permission from Hedner and Kisiel [16]