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Biophysical properties of humanized anti-TcdB MAbs
| MAb | Affinity for TcdB1234 (pM) | Valency of binding for TcdB1234 (n) | pI | Fab Tm (°C) | Resistance to shaking aggregation |
|---|---|---|---|---|---|
| CA1125 | 170 | 1 | 9.2 | 79.5 | Good |
| CA1134 | 47 | 2 | 9.3 | 76.4 | Moderate |
| CA1151 | 1,820 | 2 (1.5) | 9.2 | 80.8 | Very Good |
| CA1153 | 260 | 1 | NDa | ND | ND |
| MDX-1388 | 1570 | 2 | 9.2 | 68.2 | Good |
ND, not determined.
