Table 6.
Detection of human IgG1 in the sera of infected hamsters by an LC MS-MS assaya
| Sampling day postinfection | Serum concn in μg/ml of human IgG for MAb group indicated (animal no.): |
|||
|---|---|---|---|---|
| UCB 5 mg/kg | UCB 50 mg/kg | MDX 5 mg/kg | MDX 50 mg/kg | |
| 1 | 280 (144) | 3,050 (182) | 335 (193) | 3,040 (160) |
| 1 | 302 (145) | 2,790 (183) | 322 (194) | 3,330 (161) |
| 1 | 182 (146) | 2,370 (184) | 260 (195) | 2,990 (162) |
| 6 | 61 (145) | 838 (182) | 103 (200) | 583 (162) |
| 6 | 71 (147) | 645 (183) | 62 (202) | 913 (163) |
| 6 | 45 (149) | 855 (184) | 79 (203) | 1,240 (164) |
| 28 | —b | 116 (182) | <2.5 (203) | 199 (164) |
| 28 | — | 65 (183) | — | 36 (165) |
| 28 | — | 66 (184) | — | — |
| 28 | — | 44 (185) | — | — |
| 28 | — | 101 (186) | — | — |
| 28 | — | 89 (187) | — | — |
| 28 | — | 27 (188) | — | — |
| 28 | — | 31 (189) | — | — |
| 28 | — | 66 (190) | — | — |
a
The data represent single experimental samples and assay replicates.
b
—, no surviving animal.