Fig 6.

RV1 and RV2 virion seroreactivity of specific groups of macaques. Data from the RV1 and RV2 virion multiplex Luminex assay of Fig. 4 are shown for specific groups of macaques, including (i) juveniles (less than 13 months of age); (ii) macaques from a specific pathogen-free (SPF3) colony that have been screened for absence of D-type simian retrovirus, simian T-cell leukemia virus, and cercopithecine herpesvirus 1 (the macaque homolog of herpes simplex virus); (iii) macaques from the general colony; and (iv) macaques participating in SIV vaccine studies. The seroreactivity of the SIV vaccine animals was significantly higher than that of the general colony animals in both assays. (A) RV1 virion assay; **, P = 0.0033; (B) RV2 virion assay; ***, P = 0.0005, according to the unpaired t test, two-tailed. The seroreactivities of the SPF3 and the general colony animals were not significantly different in either assay. The RV2 seroreactivity was significantly greater than the RV1 seroreactivity within the SPF3, general colony, and SIV vaccine groups (P < 0.0001), using the paired t test, two-tailed. No difference was detected between the RV1 and RV2 seroreactivity in the juveniles. The means and standard deviation are shown.