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. Author manuscript; available in PMC: 2013 Mar 8.
Published in final edited form as: J Immunol. 2009 Jul 10;183(3):1804–1812. doi: 10.4049/jimmunol.0804206

Figure 4. SLP-76 deficient OCs mobilize in response to PTH but fail to normalize bone resorption, in vivo.

Figure 4

(A) SLP-76+/? and SLP-76−/− mice were supracalvarially injected with PTH, 4 times a day. After 4 days histological sections of calvaria stained for TRAP activity (red reaction product) (600x). (B) CTx content of serum collected at sacrifice of SLP-76+/?, SLP-76−/, control (SLP-76+/?BLNK−/−) and DKO mice. (N=4–5 in each group). (C) The number of OCs per millimeter bone surface was quantified histomorphometrically. (D) The percent of bone surface covered by OCs was quantified histomorphometrically. (E) The percent of OCs on bone was determined histomorphometrically.