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High-ploidy Mk production for 24 factorial design of experiments. Effects of 17 cocktails on (A, B) the percentage of high-ploidy (>4N) Mks and (C, D) the number of high-ploidy Mks produced per HSPC. (A, C) Cytokine cocktails are indicated by symbol and line combinations (e.g., open black diamond and solid black line), as shown in Table 1. Data represent the mean±SEM for n=5 donors. (B, D) Main and interaction cytokine effects at day 11; significant effects (p<0.05) are shaded gray.
