Figure 2.

Modeled estimation of the sensitivity of a single point-of-care circulating cathodic antigen (POC-CCA) in the five study countries (as shown in the variously thin or dotted lines as indicated in the Figure) or the five taken together (thick gray line), according to the “true” local Schistosoma mansoni prevalence of infection among 9- to 12-year-old children. Comparison is shown to results for a single Kato-Katz stool examination (thick black line). The model is based on logistic regression in which “true” disease status (yes or no) of each subject is treated as a binary latent variable, and the likelihood of schistosomiasis was hypothesized to be a function of age, gender, and community to which each subject belonged.