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(A) Structure of the blood–brain barrier, established by the endothelial cells of blood capillaries and their tight junctions (B) Different mechanisms for the transporting of substances across the blood–brain barrier. Adapted from Mol Med Today, 2, Abbott NJ, Romero IA, Transporting therapeutics across the blood-brain barrier. 106–113. Copyright (1996), with permission from Elsevier.6
