Table 1.

Radioprotective effects of SOD mimics (% Radioprotection)


		XTT				Annexin/Propidium Iodide				Gamma H2AX IRIF		Neutral Comet

Compound Name	Conq(μM)	WT (%)	Stdev	A-T (%)	Stdev	WT (%)	Stdev	A-T (%)	Stdev	WT (%)	Stdev	WT (%)	Stdev	A-T (%)	Stdev
MnMx-2-PyP-Calbio	56	25^*	7.29	−16.23	16.12	11^*	2.10	−11.50	9.96	9.96	5.77	19.99^*	17.16	0.22	14.05
MnTM-2-PyP	1	−45.74	10.91	−96.22	12.10	9.01	6.26	2.03	9.87	13.69	2.16	8.83^*	14.12	0.00	15.89
MnTE-2-PyP	1	−53.33	41.67	41.67	14.29	12.32	3.44	14.21	6.75	2.22	5.51	13.45	10.57	0.00	18.43
MnTnHex-2-PyP	1	58^*	7.32	−17.49	56.68	28.61	26.04	39^*	3.25	57^*	11.31	29.76	16.92	15.43	18.79
MnTTEG-2-PyP	1	−36.71	25.00	−81.81	61.19	3.22	0.41	4.12	10.61	19.53	12.34	18.56	16.28	0.00	14.28
MnBr8TSPP	1	5.35	4.96	−27.81	12.47	−40.58	11.55	−41.56	16.72	70.33	2.65	12.75	10.78	0.00	11.12
EUK-8	20	14.79	45.50	−14.92	14.13	−6.10	12.23	19.56	16.43	−0.43	10.41	27.66	14.61	15.86	16.50
EUK-134	10	−29.57	3.33	−50.81	4.54	7.18	9.97	8^*	4.23	52^*	4.35	21.02	27.29	0.00	20.23
EUK-189	20	−87.12	61.59	−18.76	4.36	7.25	12.09	10.95	7.82	30.31	7.12	0.00	12.57	0.00	16.14
M40404	20	1.49	12.90	−13.24	21.46	14.31	8.25	4.36	1.63	−60.78	3.24	44.50	12.56	28.04	44.87
M40403	20	−11.04	4.49	−15.78	11.60	33.02	19.96	5.04	4.86	−45.54	3.30	35.66	15.46	0.00	18.75
MnCl₂	1	31^*	0.55	16.00	12.94	11.69	17.19	−5.12	6.47	22.79	13.00	21.89	20.13	0.00	35.97

% Protection is shown as $[\frac{(IR + vehicle) - (IR + compound-treated)}{(IR + vehicle)} \times 100 %]$ Student’s t-test was used to measure statistical significance.

P value ≤ 0.1