Figure 10.

Temporal summation. A network of two neurons with an excitatory synapse from cell A to cell B. A: Two presynaptic action potentials are elicited with an interspike interval of 100 ms. The individual EPSPs are subthreshold for eliciting a postsynaptic spike. B: If the interspike interval is reduced to 50 ms, the EPSPs summate and elicit a postsynaptic spike. The temporal summation of the two EPSPs produces a suprathreshold depolarization in the postsynaptic cell and a spike is elicited.