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. 2013 Mar 8;8(3):e58662. doi: 10.1371/journal.pone.0058662

Figure 8. A schematic diagram explains mechanisms by which hypoxia and glucose deprivation regulates IL-6 gene expression in BV2 microglia.

Figure 8

Glucose deprivation or SERCA inhibition increases cytoplasmic calcium ion concentration and induces IL-6 gene expression by activating NFκB and p38. Hypoxia down-regulates IL-6 gene expression by activating the Akt pathway.